Checking in with your doctor

Your doctor will likely want to see you regularly to check that CABLIVI is working for you.

It is important that you go to all follow-up appointments arranged by your doctor, as they may need to make changes to your treatment. Follow-up appointments are also a good time for you to ask questions or let your doctor know about any side effects you may have experienced, even those that may not seem serious.

Male patient with doctor

Watch for the return of any aTTP symptoms. If you think that you have any symptoms of an aTTP episode, visit your local emergency room right away

Tell your doctor if:

  • You bleed excessively during treatment. Your doctor may ask you to stop treatment, and they will decide when you can start your treatment again
  • You are using blood thinners (heparin, warfarin, rivaroxaban, apixaban, etc)
  • You have a bleeding disorder such as hemophilia. Your doctor will decide how you should be treated
  • You have history of liver issues
  • You are going to have an operation or dental treatment. Your doctor may advise you to postpone or stop CABLIVI before your surgery or dental work

Sample questions for your doctor

1. How will I know that CABLIVI is working?

2. How long will I need to take CABLIVI?

3. Will I continue to have symptoms of aTTP after I take CABLIVI?

4. Is there anything I can do to prevent another aTTP episode?

For a full list of questions, download the CABLIVI Doctor Discussion Guide.

CABLIVI Doctor Discussion Guide

Suggested questions to ask your doctor about treatment with CABLIVI.

Download the doctor discussion guide >


Who should not take CABLIVI?

Do not take CABLIVI if you’ve had an allergic reaction to caplacizumab-yhdp or to any of the ingredients in CABLIVI.

What should I tell my healthcare team before starting CABLIVI?

Tell your doctor if you have a medical condition including if you have a bleeding disorder. Tell your doctor about any medicines you take.

Talk to your doctor before scheduling any surgery, medical or dental procedure.

What are the possible side effects of CABLIVI?

CABLIVI can cause severe bleeding. In clinical studies, severe bleeding adverse reactions of nosebleed, bleeding from the gums, bleeding in the stomach or intestines, and bleeding from the uterus were each reported in 1% of subjects. Contact your doctor immediately if excessive bleeding or bruising occur.

You may have a higher risk of bleeding if you have a bleeding disorder (i.e. hemophilia) or if you take other medicines that increase your risk of bleeding such as anti-coagulants.

CABLIVI should be stopped for 7 days before surgery or any medical or dental procedure. Talk to your doctor before you stop taking CABLIVI.

The most common side effects include nosebleed, headache and bleeding gums.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of CABLIVI. Call your doctor for medical advice about side effects.


What is CABLIVI?

CABLIVI (caplacizumab-yhdp) is a prescription medicine used for the treatment of adults with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

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TTP=thrombotic thrombocytopenic purpura.