How is aTTP treated?

Potential treatments

Your doctor will decide what treatment is best
for you. It is common for aTTP to be treated
with plasma exchange Plasma exchange: A procedure that removes and replaces a person’s blood plasma. This process helps clean the body by removing things it has too much of (such as immune cells) and adding things it has too little of (such as ADAMTS13 and platelets). and
immunosuppressive therapy Immunosuppressive therapy/immunosuppressant: Treatment that helps decrease the activity of the immune system. .

Plasma exchange (sometimes abbreviated as PEX/TPE or called apheresis or plasmapheresis )

Plasma exchange is a procedure that removes and replaces a person’s blood plasma. This process helps clean your blood by removing things you have too much of (such as immune cells) and adding things you have too little of (such as ADAMTS13 enzymes and platelets). This treatment usually takes a couple of hours each day and may need to be done for several days or weeks.

Immunosuppressive therapy/
Immunosuppressant

Immunosuppressive therapy is a medicine that helps decrease the activity of your
immune system Immune system: The body’s natural defense system against a harmful organism that can make you sick. , which is overactive during an episode of aTTP.

Prescription medicine designed specifically for aTTP

CABLIVI is approved to treat adults with aTTP. It is meant to prevent your body from forming blood clots, and it works together with plasma exchange and immunosuppressive therapy.

Meet your healthcare team

Below are some of the professionals you may come across during treatment. Because everyone’s experience with aTTP is different, you may not have the same healthcare team that is listed below.

In the hospital

Blood drops

Hematologist (or hematologist-oncologist)

A hematologist is a doctor who focuses on diagnosing, treating, and/or preventing blood disorders. A hematologist-oncologist is a doctor who focuses on both blood disorders and blood cancer.

Your hematologist is likely to be your main point of contact when you’re in the hospital. They will talk to you about aTTP and your treatment plan.

Kidneys

Nephrologist

A nephrologist is a doctor who focuses on conditions that affect the kidneys.

Nephrologists administer plasma exchange at some hospitals. If that’s the case for your hospital, your nephrologist may be your main point of contact. They will likely work with a
hematologist for your treatment.

Intravenous bag

Pathologist/Transfusion Medicine Specialist

A pathologist studies the causes and effects of conditions and may administer plasma exchange. A transfusion medicine specialist is knowledgeable about all aspects of blood banking and transfusion medicine. A pathologist can also specialize in transfusion medicine.

Your pathologist or transfusion medicine specialist may work with your hematologist or nephrologist to help find the
cause of your symptoms.

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Nurse

A nurse works with doctors and other healthcare team members to care for people being treated.

Your nurse may assist you throughout treatment during your time at the hospital and when it’s time for you to go home.

After the hospital

Blood drops

Hematologist

After leaving the hospital, you should continue to check in with your hematologist as often as they recommend.

Stethoscope

Primary Care Physician

Your primary care physician may want to see you regularly to see how you’re doing.

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Nurse

Your nurse may assist with your treatment after you’ve left the hospital.

IMPORTANT SAFETY INFORMATION

Who should not take CABLIVI?

Do not take CABLIVI if you’ve had an allergic reaction to caplacizumab-yhdp or to any of the ingredients in CABLIVI.

What should I tell my healthcare team before starting CABLIVI?

Tell your doctor if you have a medical condition including if you have a bleeding disorder. Tell your doctor about any medicines you take.

Talk to your doctor before scheduling any surgery, medical or dental procedure.

What are the possible side effects of CABLIVI?

CABLIVI can cause severe bleeding. In clinical studies, severe bleeding adverse reactions of nosebleed, bleeding from the gums, bleeding in the stomach or intestines, and bleeding from the uterus were each reported in 1% of subjects. Contact your doctor immediately if excessive bleeding or bruising occur.

You may have a higher risk of bleeding if you have a bleeding disorder (i.e. hemophilia) or if you take other medicines that increase your risk of bleeding such as anti-coagulants.

CABLIVI should be stopped for 7 days before surgery or any medical or dental procedure. Talk to your doctor before you stop taking CABLIVI.

The most common side effects include nosebleed, headache and bleeding gums.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of CABLIVI. Call your doctor for medical advice about side effects.

INDICATION

What is CABLIVI?

CABLIVI (caplacizumab-yhdp) is a prescription medicine used for the treatment of adults with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

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