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How is aTTP/iTTP* treated?

Potential aTTP/iTTP treatments are given with 2 major therapeutic goals:

  1. Treat low platelet count
  2. Protect from autoimmune response against ADAMTS13 enzymes

Your doctor will decide what treatment is best for you. It is common for aTTP/iTTP to be treated with plasma exchange and immunosuppressive therapy.

*aTTP is also known as iTTP. The terms can be used interchangeably.

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Plasma exchange (sometimes abbreviated as PEX/TPE or called apheresis or plasmapheresis)

  • Plasma exchange is a procedure that removes and replaces a person's blood plasma.
  • This process helps clean your blood by removing things you have too much of (such as immune cells) and adding things you have too little of (such as ADAMTS13 enzymes and platelets).
  • This treatment usually takes a couple of hours each day and may need to be done for several days or weeks.

Immunosuppressive therapy/Immunosuppressant

Immunosuppressive therapy is a medicine that helps decrease the activity of your immune system, which is overactive during an episode of aTTP/iTTP.

Prescription medicine designed specifically for aTTP/iTTP

CABLIVI is approved to treat adults with aTTP/iTTP. It is meant to prevent your body from forming blood clots, and it works together with plasma exchange and immunosuppressive therapy.

Meet your healthcare team

Below are some of the professionals you may come across during treatment. Because everyone's experience with aTTP/iTTP is different, you may not have the same healthcare team.

In the hospital

Hematologist (or hematologist-oncologist)

A hematologist is a doctor who focuses on diagnosing, treating, and/or preventing blood disorders. A hematologist-oncologist is a doctor who focuses on both blood disorders and blood cancer.

Your hematologist is likely to be your main point of contact when you're being treated for aTTP/iTTP in the hospital. They will talk to you about aTTP/iTTP and your treatment plan.

Nephrologist

A nephrologist is a doctor who focuses on conditions that affect the kidneys.

Nephrologists administer plasma exchange at some hospitals. If that's the case for your hospital, your nephrologist may be your main point of contact. They will likely work with a hematologist for your treatment.

Pathologist/Transfusion Medicine Specialist

A pathologist studies the causes and effects of conditions and may administer plasma exchange. A transfusion medicine specialist is knowledgeable about all aspects of blood banking and transfusion medicine. A pathologist can also specialize in transfusion medicine.

Your pathologist or transfusion medicine specialist may work with your hematologist or nephrologist to help find the cause of your symptoms.

Nurse

A nurse works with doctors and other healthcare team members to care for people being treated.

Your nurse may assist you throughout treatment during your time at the hospital and when it's time for you to go home.

After the hospital

Hematologist

After leaving the hospital, you should continue to check in with your hematologist as often as they recommend.

Primary Care Physician

Your primary care physician may want to see you regularly to see how you're doing.

Nurse

Your nurse may assist with your treatment after you've left the hospital.

Specialty Pharmacy Services

The specialty pharmacy coordinates direct-to-home shipment of CABLIVI for a seamless transition upon discharge.

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James is being compensated by Sanofi.

CABLIVI can help make a difference

See how CABLIVI may help you

CABLIVI treatment starts in the hospital

Learn how to take CABLIVI
IMPORTANT SAFETY INFORMATION AND INDICATIONS
Who should not take CABLIVI?

Do not take CABLIVI if you've had an allergic reaction to caplacizumab-yhdp or to any of the ingredients in CABLIVI.

What should I tell my healthcare team before starting CABLIVI?
Add
IMPORTANT SAFETY INFORMATION AND INDICATIONS
What is CABLIVI?

CABLIVI (caplacizumab-yhdp) is a prescription medicine used for the treatment of adults with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

Who should not take CABLIVI?

Do not take CABLIVI if you've had an allergic reaction to caplacizumab-yhdp or to any of the ingredients in CABLIVI.

What should I tell my healthcare team before starting CABLIVI?

Tell your doctor if you have a medical condition including if you have a bleeding disorder. Tell your doctor about any medicines you take, including medicines that increase your risk of bleeding such as anti-coagulants and anti-platelet agents.

Talk to your doctor before scheduling any surgery, medical or dental procedure.

What are the possible side effects of CABLIVI?

CABLIVI can cause severe bleeding. In clinical studies, severe bleeding adverse reactions of nosebleed, bleeding from the gums, bleeding in the stomach or intestines, and bleeding from the uterus were each reported in 1% of subjects. In the post-marketing setting, cases of life-threatening and fatal bleeding were reported in patients receiving CABLIVI. Contact your doctor immediately if symptoms of excessive bruising, excessive bleeding, or major bleeding occur. Signs and symptoms of bleeding include: pain, swelling or discomfort, prolonged bleeding from cuts, increased menstrual flow or vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or dark brown urine, red or tar black stools, headache, dizziness, or weakness.

You may have a higher risk of bleeding if you have a bleeding disorder (i.e. hemophilia) or if you take other medicines that increase your risk of bleeding such as anti-coagulants and anti-platelet agents.

CABLIVI should be stopped for 7 days before surgery or any medical or dental procedure. Talk to your doctor before you stop taking CABLIVI.

The most common side effects include nosebleed, headache and bleeding gums.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of CABLIVI. Call your doctor for medical advice about side effects.

Please see full Prescribing Information
Instructions for Use
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