CABLIVI is a daily treatment that starts in the hospital and continues at home

It is recommended to take CABLIVI every day you receive plasma exchange and for 30 days after your last plasma exchange session. Your doctor may decide you need to take CABLIVI for more than 30 days. This additional period may last up to 28 days.

aTTP/iTTP* is a serious condition that requires quick treatment

If you or someone you love has been diagnosed with acquired/immune-mediated thrombotic thrombocytopenic purpura (aTTP/iTTP), the plasma exchange procedure will start as soon as possible. It is recommended that CABLIVI start on the first day of plasma exchange.

Who should not start CABLIVI?

  • Do not take CABLIVI if you’ve had an allergic reaction to caplacizumab-yhdp or any of the ingredients in CABLIVI
  • CABLIVI should be stopped for 7 days before surgery or any medical or dental procedure. Talk to your doctor before stopping CABLIVI

Talk with your care team if you think CABLIVI may be right for you.

Hospital icon

What to expect in the hospital

DAY 1

You will receive 2 doses of CABLIVI on day 1

First dose: Your care team will give the first dose of CABLIVI through an IV injection before your first plasma exchange session

Second dose: Your care team will give the second dose of CABLIVI as an injection into the skin of your stomach after your first plasma exchange session

HOSPITAL STAY
(number of days can vary)

Every day after day 1, CABLIVI will be given after each plasma exchange session as an injection into the skin of your stomach

Each person receives plasma exchange sessions for a different number of days. Your doctor will decide how many plasma exchange sessions you need

After plasma exchange is no longer needed, you will continue to receive a CABLIVI injection daily for the remainder of your stay and begin to prepare to take CABLIVI at home every day

Experiencing an aTTP/iTTP episode and starting a new therapy can be overwhelming, but your care team and CABLIVI Patient Solutions are here to help

Your doctor and your care team are the best source of information. Be sure to ask them any questions you may have as you start treatment and talk with them about continuing CABLIVI at home before you leave the hospital.

See tips for how to talk with your care team >

    Hematologist (or hematologist-oncologist)

    A hematologist is a doctor who focuses on diagnosing, treating, and/or preventing blood disorders. A hematologist-oncologist is a doctor who focuses on both blood disorders and blood cancer.

    Your hematologist is likely to be your main point of contact when you’re being treated for aTTP/iTTP in the hospital. They will talk to you about aTTP/iTTP and your treatment plan.

    Nephrologist

    A nephrologist is a doctor who focuses on conditions that affect the kidneys.

    Nephrologists administer plasma exchange at some hospitals. If that’s the case for your hospital, your nephrologist may be your main point of contact. They will likely work with a hematologist for your treatment.

    Pathologist/Transfusion Medicine Specialist

    A pathologist studies the causes and effects of conditions and may administer plasma exchange. A transfusion medicine specialist is knowledgeable about all aspects of blood banking and transfusion medicine. A pathologist can also specialize in transfusion medicine.

    Your pathologist or transfusion medicine specialist may work with your hematologist or nephrologist to help find the cause of your symptoms.

    Nurse

    A nurse works with doctors and other healthcare team members to care for people being treated.

    Your nurse may assist you throughout treatment during your time at the hospital and when it’s time for you to go home.

CABLIVI Patient Solutions is dedicated to supporting people with aTTP/iTTP even if you’re not prescribed CABLIVI

  • aTTP/iTTP education is available to everyone
  • Seamless support from hospital to home with CABLIVI Patient Solutions, including education, training to taking CABLIVI at home, and financial assistance for eligible patients

Discover the support available through CABLIVI Patient Solutions >

or

Enroll today >

Hear about Alex’s experience with aTTP/iTTP

“On my second experience with aTTP/iTTP, my new doctor mentioned that there was a medication that could be helpful for me called CABLIVI.”

Alex, real patient. Individual results may vary. Alex is being compensated by Sanofi.

    CABLIVI (caplacizumab-yhdp) is a prescription medicine used for the treatment of adults with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy. Please stay tuned for the Important Safety Information at the end of this video.

    My name is Alex.

    *Alex was compensated for his time in the creation of this video.*

    I am a husband, I’m a father, I’m a musician. And two years ago, I was diagnosed with aTTP.

    My first experience with aTTP was pretty scary. I was on my way to work, and then half of my body went numb. So, I drove myself to the urgent care, and they basically said, “It sounds like you had a ministroke. You might want to go to the ER because there’s nothing we can do for you.”

    The first time I was in the hospital, I had a very extended stay. Not knowing what’s wrong with you is just so frightening. You know they’re testing for so many things, and everything comes back negative.

    My platelet count kept going down, it just wasn’t improving. Having all these doctors around you, that look kind of concerned because they can’t figure out what’s wrong with you. You sort of want to keep hope, but you somehow also start beginning to lose hope. All you can do is just be patient and hope they figure it out.

    They finally diagnosed me with aTTP. I just felt so relieved that they finally figured out what was wrong. On my second experience with aTTP, my new doctor mentioned that there was a medication that could be helpful for me called CABLIVI.

    Once I had aTTP again, my main concern was bringing up my platelet counts. So, learning that CABLIVI, along with immunosuppressants and plasma exchange, could help platelet count to a normal level faster, it’s like OK, let’s do this. What do we do? What’s the treatment plan?

    The only thing I could think about then was just being home with my family, with my music career. I just wanted things back the way they were.

    Within 3 days of starting CABLIVI, my platelet count returned to a normal level. After 7 days, I was well enough to go home.

    *CABLIVI was tested in a clinical study of 145 adults with aTTP/iTTP. 72 people were given CABLIVI, plasma exchange (PEX), and immunosuppressive therapy vs 73 people who were given placebo (an injection without any medicine), PEX, and immunosuppressive therapy. Both groups received either CABLIVI or placebo after their daily PEX, and then for 30 days after. Some people received more treatment (up to 28 additional days) based on their doctor’s decision. After treatment was stopped, everyone was followed by their doctor for 28 more days.*

    My doctor explained that taking CABLIVI had certain side effects, but thankfully I didn’t experience any.

    *The most common side effects include nosebleed, headache and bleeding gums. Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of CABLIVI. Call your doctor for medical advice about side effects.*

    Once I was released from the hospital and I continued my medication at home, I had no issues with self-injecting, the nurses at the hospital showed me how to do it, and I was confident that I could do it at home.

    I didn’t have any relapses during my CABLIVI treatment, or for 28 days after.

    *Significantly fewer people had another episode of aTTP/iTTP that required starting PEX again within the full study period (while taking CABLIVI and 28 days after stopping CABLIVI) in the CABLIVI group vs the placebo group: 13% receiving CABLIVI (9 people) vs 38% receiving placebo (28 people). Individual results may vary.*

    So my life today is just staying on top of my symptoms. I just feel more confident and I was ready to move forward with my life. Appreciate my family, and my music career. I can do the things that I wanted to do, and still live a fulfilling life. Even if I'm living with aTTP.

    This was Alex's personal experience with CABLIVI. Every patient's experience is unique and individual results will vary. If you're interested in learning more, please speak with your doctor about the potential benefits and risks of treatment with CABLIVI and whether CABLIVI may be right for you.

    INDICATION AND IMPORTANT SAFETY INFORMATION
    What is CABLIVI?
    CABLIVI (caplacizumab-yhdp) is a prescription medicine used for the treatment of adults with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

    Who should not take CABLIVI?
    Do not take CABLIVI if you've had an allergic reaction to caplacizumab-yhdp or to any of the ingredients in CABLIVI.

    What should I tell my healthcare team before starting CABLIVI?
    Tell your doctor if you have a medical condition including if you have a bleeding disorder. Tell your doctor about any medicines you take, including medicines that increase your risk of bleeding such as anti-coagulants and anti-platelet agents.

    Talk to your doctor before scheduling any surgery, medical or dental procedure.

    What are the possible side effects of CABLIVI?
    CABLIVI can cause severe bleeding. In clinical studies, severe bleeding adverse reactions of nosebleed, bleeding from the gums, bleeding in the stomach or intestines, and bleeding from the uterus were each reported in 1% of subjects. In the post-marketing setting, cases of life-threatening and fatal bleeding were reported in patients receiving CABLIVI. Contact your doctor immediately if symptoms of excessive bruising, excessive bleeding, or major bleeding occur. Signs and symptoms of bleeding include: pain, swelling or discomfort, prolonged bleeding from cuts, increased menstrual flow or vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or dark brown urine, red or tar black stools, headache, dizziness, or weakness.

    You may have a higher risk of bleeding if you have a bleeding disorder (i.e. hemophilia) or if you take other medicines that increase your risk of bleeding such as anti-coagulants and anti-platelet agents.

    CABLIVI should be stopped for 7 days before surgery or any medical or dental procedure. Talk to your doctor before you stop taking CABLIVI.

    The most common side effects include nosebleed, headache and bleeding gums.

    Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of CABLIVI. Call your doctor for medical advice about side effects.

    Please see accompanying full Prescribing Information.

CABLIVI treatment continues from hospital to home

CABLIVI Patient Solutions is dedicated to your needs, from starting CABLIVI in the hospital to continuing at home

*aTTP is also known as iTTP. You and your healthcare team can use either term.
aTTP/iTTP=acquired/immune-mediated thrombotic thrombocytopenic purpura.

IMPORTANT SAFETY INFORMATION AND INDICATIONS