Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare, life-threatening blood disorder

aTTP is also known as immune-mediated thrombotic thrombocytopenic purpura (iTTP). aTTP and iTTP are the same condition. Your healthcare team may use either term.

The words that make up aTTP/iTTP help explain what is happening in the body

Question mark icon

Acquired means you were not born with the condition. It is something you developed later in life. The main cause is not known. Immune-mediated means the cause of the condition is not known, but happens when the immune system isn’t working normally.

Blood vessel with blood clot icon

Thrombotic means blood clots form in the blood vessels. In aTTP/iTTP, small blood clots can form throughout the body.

Platelets icon

Thrombocytopenic means having a lower number of blood platelets than you should. This happens because the platelets clump together to make blood clots throughout the body.

Purpura icon

Purpura are purple bruises that are caused by bleeding under your skin. These bruises are a key symptom of aTTP/iTTP.

Patient, Heather,  facing camera

Heather, real patient. Individual results may vary. Heather is being compensated by Sanofi.

Even though aTTP/iTTP is a rare condition, you are not alone and CABLIVI, in combination with PEX and immunosuppression, can help.

Hear other people’s stories about CABLIVI >

CABLIVI is a breakthrough treatment for aTTP/iTTP designed to prevent blood clots

Ribbon icon

The first and only FDA-approved treatment that works with plasma exchange and immunosuppression to take on aTTP/iTTP in adults

Recommended icon

Learn more about ISTH treatment guidelines and CABLIVI

Patient, Heather,  facing camera and smiling

Heather, real patient. Individual results may vary. Heather is being compensated by Sanofi.

CABLIVI, in combination with PEX and immunosuppression, can make a difference in your treatment.

See how >

You and your loved ones play an important role in your treatment

You play an important role in managing your own health. Talking with your doctor can help you get the most out of your aTTP/iTTP treatment. You can talk with them about anything, from what tests they’re doing to whether you are getting the aTTP/iTTP treatments that experts recommend. Talking to healthcare providers can feel scary or unsettling. If this is the case for you, you’re not the only one. Below are some tips to get you and your loved ones started.

Read more about how you can help someone with aTTP/iTTP >

Tips for talking with your care team about treatment options

  • Think about the questions you want to ask and write them down. Have your questions ready for the next time the doctor visits your room. It’s OK if you have new questions every day. It might help to keep a list in one place (like a planner or phone) so you can grab it whenever you talk with your care team
  • It’s OK to ask a question twice. Or 3 or 4 times! It’s better to keep asking until you understand than to leave the conversation still feeling confused
  • If possible, have a loved one in the room to help ask questions and hear your doctor’s answers. It can be hard to remember everything you want to ask or everything your doctor said. Having a loved one be a second set of ears can be helpful
  • Be your own best advocate by asking for all available treatment options, including CABLIVI. It might feel uncomfortable to ask, but just be honest. Tell them how you’re feeling and why you’re asking. You might want to start with something like, “I’m feeling scared and anxious, and I just want to make sure we’re doing everything possible to help get this under control”
  • Learn together. Remember that your care team might not be familiar with aTTP/iTTP because it’s so rare. You can ask if they have heard of CABLIVI or if they have seen the ISTH Guidelines and how those play into your treatment plan. You can also ask if they have any resources that will help you learn more about aTTP/iTTP and CABLIVI

Some questions you may want to ask when starting treatment

  • Can you walk me through my treatment plan? It would help if you could explain the different parts or steps

  • Am I an appropriate candidate for CABLIVI?

  • How will you know if my treatments are working?

Want to know more about aTTP/iTTP?

Want to better understand how aTTP/iTTP is treated?

aTTP/iTTP=acquired/immune-mediated thrombotic thrombocytopenic purpura; FDA=Food and Drug Administration; ISTH=International Society on Thrombosis and Haemostasis.